• We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.

Our Core Research Team

We are nine independent laboratories working together to research (i) mechanisms of DNA damage and repair, (ii) translational applications of genome instability to the clinic and (iii) the pathways underlying human cellular aging.

Dr. Gwyn Bebb

Dr. Gwyn Bebb

Genome instability markers in human lung cancer and lymphoma.

Short Bio Summary

Dr. Gwyn Bebb is a medical oncologist at the Tom Baker Cancer Centre and an associate professor at the
Arnie Charbonneau Cancer Institute; he also leads the Tom Baker Cancer Centre’s Clinical Research
Unit. He obtained his MD from Oxford University (UK) in 1992 and his PhD from the University of British Columbia
in 1999. In 2004, he opened his own laboratory at the University of Calgary’s Cumming School of Medicine.

Research Interests

In humans, the ATM gene encodes a protein that is critical for preserving genome stability by ensuring a proper cellular response to DNA damage. People born without ATM suffer from the heritable disorder called Ataxia Telangiectasia, characterized (among other symptoms) by increased sensitivity to DNA damage and an elevated risk of cancer. Within the general population, several cancers are now known to show mutations in ATM, including mantle cell lymphoma (MCC, a type of blood cancer) and non-small cell lung cancer (NSCLC).

Our research is focused on targeted therapy of MCC and NSCLC. To facilitate translational research in lung cancer, Dr Bebb led the creation of the Glans-Look lung cancer database, collecting clinical information on almost 6,000 lung cancer patients from the Calgary area, with matching cancer specimens (for most) available for researchers.

Laboratory Members

Research Associate:
Lars Petersen
MSc Student:
Roxana Tudor
MSc Student:
Jarrett Moorre

Productivity & Funding

Publications

pubmed


 

Current Funding