• We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.

Our Core Research Team

We are nine independent laboratories working together to research (i) mechanisms of DNA damage and repair, (ii) translational applications of genome instability to the clinic and (iii) the pathways underlying human cellular aging.

Dr. Jennifer Cobb

Dr. Jennifer Cobb

Genome instability as a consequence of replication of fragile DNA sites.

Short Bio Summary

Dr. Cobb is an Associate Professor in the Departments of Biochemistry & Molecular Biology and Oncology and the co-Lead for Research at the Arnie Charbonneau Cancer Institute. She obtained her PhD from University of Tennessee in 2000 and trained at the University of Geneva, Switzerland until the end 2006. In 2007, she opened her own laboratory at the University of Calgary’s Cumming School of Medicine.

Research Interests

Aging is the primary determinant of cancer, but our knowledge about why cells cease to function over time remains largely obscure. One important factor that coincides with aging is the observation that DNA damage increases in cells that have naturally aged and in cells derived from organisms with premature aging syndrome. Age-related changes in DNA repair mechanisms are likely to provide insight into molecular changes that underscore tumor development.

Our research focuses on the mechanisms of DNA repair and replication in the context of chromatin and nuclear organization. Our aim is to understand how these processes change during aging and in the early events of tumorigenesis. Ongoing projects involve characterizing epigenetic and nuclear organization changes during aging and how these alterations impact genomic stability in Saccharomyces cerevisiae (budding yeast) and human cells.

Laboratory Members

Lab Manager:
Shilpa Salgia
Lab Technician:
Carin Pihl
Research Associate:
Mireille Tittel-Elmer
Post Doctoral Fellow:
Jessica Sarthi
Post Doctoral Fellow:
Musinu Sakari
Post Doctoral Fellow:
Sarah Moradi-Fard
Post Doctoral Fellow:
Kyle Sorenson
PhD Student:
Nicola Mair
PhD Student:
Gaby Wishart
MSc Student:
William McLaren
Summer Student:
Megan Chan
Summer Student:
Astha Burande

Productivity & Funding

Publications

pubmed

Media

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Current Funding

irsc-cihrPrint