• We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.

Our Core Research Team

We are nine independent laboratories working together to research (i) mechanisms of DNA damage and repair, (ii) translational applications of genome instability to the clinic and (iii) the pathways underlying human cellular aging.

Dr. Aaron Goodarzi

Dr. Aaron Goodarzi

Chromatin dynamics during DNA damage responses to radiation exposure.

Short Bio Summary

Dr. Goodarzi is the Canada Research Chair for Genome Damage and Instability Disease and is both the Education Lead and Microscopy Lead for the University of Calgary’s Arnie Charbonneau Cancer Institute. He obtained his PhD from University of Calgary in 2005 and trained as a post doctoral scholar at the Genome Damage and Stability Centre at the University of Sussex (UK) until 2010. In 2011, he opened his own laboratory at the University of Calgary’s Cumming School of Medicine. In 2015, he was named one of Calgary's Top 40 Under 40 for achievements in science and education and, in 2016, was named a "Peak Scholar" by University of Calgary President Elizabeth Cannon for his efforts in knowledge engagement in the area of the health impact of radon gas inhalation.

Research Interests

From the moment of our conception, our DNA is subject to damage, the most serious form being a break in both strands of the DNA double helix. Unless these breaks are resealed correctly, whole segments of our genome can be lost or irrevocably mutated to fuel a self-propagating process of volatility that underlies cancer formation, radiation poisoning and/or premature cellular aging.

Our research focuses on slow-repairing DNA double strand breaks, particularly those induced within densely compacted heterochromatin or by high linear energy transfer ionizing radiation such as alpha particles emitted by radon gas. We are especially curious about DNA double-strand break repair processes involving nucleosome remodeling enzymes. Discoveries in these areas are improving our knowledge of cancer formation, human ageing and radiation protection.

Laboratory Members

Lab Manager:
Shilpa Salgia
Lab Technician:
Carin Pihl
Lab Technician:
Shujuan Fang
Post Doctoral Fellow:
Wilson Nartey
PhD Student:
Shaun Moore
PhD Student:
Fintan Stanley
PhD Student:
Dustin Pearson
PhD/MD Student:
Daniel Berger
Summer Student 2017:
James Johnston
Summer Student 2017:
Jesse Irvine

Productivity & Funding

Publications

pubmed

Media

facebook

Current Funding

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Our annual lab photo shoot!

Lab 2015-16 Low Res

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