• We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.

Our Core Research Team

We are nine independent laboratories working together to research (i) mechanisms of DNA damage and repair, (ii) translational applications of genome instability to the clinic and (iii) the pathways underlying human cellular aging.

Dr. Ebba Kurz

Dr. Ebba Kurz

Pharmacologic studies of genome instability & topoisomerase function.

Short Bio Summary

Dr. Kurz is an Associate Professor in the Department of Physiology & Pharmacology, Director of the O’Brien Centre for the Bachelor of Health Sciences program and the Associate Dean (Undergraduate Health & Science Education) in the Cumming School of Medicine. She obtained her PhD from Queen’s University (Kingston, ON) and undertook post-doctoral training at the University of Colorado Health Sciences Center and the University of Calgary before opening her own lab in Calgary in 2006.

Research Interests

For a cell to grow and divide, its DNA must be accurately copied and equally distributed into daughter cells. Faulty regulation of these processes can lead to genomic instability, the accumulation of mutations and the development of cancer. Our laboratory studies topoisomerase II (topo II), an essential enzyme that has the formidable task of untangling intertwined DNA. Topo II is also the target of a number of widely used anti-cancer chemotherapeutics.

Our research focuses on two areas. 1) We are examining the emerging roles of topo II in DNA damage and repair. 2) We are following upon our identification of salicylate, the primary metabolite of aspirin, as a novel catalytic inhibitor of topo IIα that decreases the cytotoxicity of common chemotherapeutics. We are now exploring the impact of salicylates on treatment efficacy in a breast tumour model.

Laboratory Members

Research Associate:
Zhili Kang

Productivity & Funding

Publications

pubmed

Bachelor of Health Science Program

http://cumming.ucalgary.ca/bhsc/

Current Funding

casnadian-breast-cancer-foundation