Our Core Research Team
We are nine independent laboratories working together to research (i) mechanisms of DNA damage and repair, (ii) translational applications of genome instability to the clinic and (iii) the pathways underlying human cellular aging.
DNA Damage & Repair Researchers
Cellular Aging Researchers
Dr. Susan Lees-Miller
Short Bio Summary
Dr. Lees-Miller is a fellow of the Royal Society of Canada, holder of the University of Calgary/Alberta Cancer Foundation Engineered Air Chair in Cancer Research and the lead of the Robson DNA Science Centre (RDSC) at the Arnie Charbonneau Cancer Institute at the University of Calgary. She obtained her PhD from the University of Wales then carried out post-doctoral training at the University of Alberta and Brookhaven National Laboratory (US). In 1993, she joined the Faculty at University of Calgary and is currently a full professor in the Departments of Biochemistry and Molecular Biology and Oncology in the Cumming School of Medicine.
The Lees-Miller lab studies how cells respond to DNA damaging agents, in particular ionizing radiation (IR). Of particular interest is the mechanism of non-homologous end joining (NHEJ), the major pathway for the repair of IR-induced DNA double strand breaks (DSBs), and the role of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in DSB repair and mitosis. We are also interested in translating our work on DNA repair pathways to improve treatments for cancer patients. In collaboration with Dr. Corinne Doll we are studying the effects of PI3 kinase mutation on the response of cervical cancer cells to IR and cisplatin, and with Dr. Gwyn Bebb the effects of PARP inhibitors on ATM deficient cancer cells.