• We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.
  • We are scientists and clinical researchers determining how genome instability arises following DNA damage and during cellular aging.

Our Core Research Team

We are nine independent laboratories working together to research (i) mechanisms of DNA damage and repair, (ii) translational applications of genome instability to the clinic and (iii) the pathways underlying human cellular aging.

Dr. Susan Lees-Miller

Dr. Susan Lees-Miller

Molecular mechanisms of DNA double strand break repair and mitosis.

Short Bio Summary

Dr. Lees-Miller is a fellow of the Royal Society of Canada, holder of the University of Calgary/Alberta Cancer Foundation Engineered Air Chair in Cancer Research and the lead of the Robson DNA Science Centre (RDSC) at the Arnie Charbonneau Cancer Institute at the University of Calgary. She obtained her PhD from the University of Wales then carried out post-doctoral training at the University of Alberta and Brookhaven National Laboratory (US). In 1993, she joined the Faculty at University of Calgary and is currently a full professor in the Departments of Biochemistry and Molecular Biology and Oncology in the Cumming School of Medicine.

Research Interests

The Lees-Miller lab studies how cells respond to DNA damaging agents, in particular ionizing radiation (IR). Of particular interest is the mechanism of non-homologous end joining (NHEJ), the major pathway for the repair of IR-induced DNA double strand breaks (DSBs), and the role of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in DSB repair and mitosis. We are also interested in translating our work on DNA repair pathways to improve treatments for cancer patients. In collaboration with Dr. Corinne Doll we are studying the effects of PI3 kinase mutation on the response of cervical cancer cells to IR and cisplatin, and with Dr. Gwyn Bebb the effects of PARP inhibitors on ATM deficient cancer cells.

Laboratory Members

Lab Manager:
Shilpa Salgia
Research Associate:
Pauline Douglas
Research Associate:
Ruiqiong Ye
Research Assistant:
Shujuan Fang
Post Doctoral Fellow:
Arjumand Wani
PhD student:
Nicholas Jette

Productivity & Funding

Publications

pubmed

Current Funding

alberta-innovates-health-solutionsirsc-cihrnih