Our Core Research Team
We are nine independent laboratories working together to research (i) mechanisms of DNA damage and repair, (ii) translational applications of genome instability to the clinic and (iii) the pathways underlying human cellular aging.
DNA Damage & Repair Researchers
Cellular Aging Researchers
Dr. Gareth Williams
Short Bio Summary
Dr. Williams is an Assistant Professor in the Department of Biochemistry & Molecular Biology. He earned his PhD from the University of St Andrews (Scotland, UK) in 2006 and trained at Lawrence Berkeley National Laboratory (California, USA) until the end of 2015. In 2016, he opened his own laboratory within the Arnie Charbonneau Cancer Institute at the University of Calgary’s Cumming School of Medicine.
Our lab studies the molecular basis for how cells accurately repair damaged DNA, which plays an essential role in protecting against cancer by maintaining genome stability. In particular, we focus on the homologous recombination DNA repair pathway, which is important to accurately fix DNA double strand breaks, the most toxic form of DNA damage, and repair damaged replication forks.
Our research uses structural biology techniques to determine the molecular details of how proteins function as machines to accurately repair DNA. The structure-based mechanisms that arise from our work provide a molecular framework that can be used to understand how defects in the DNA repair process can lead to cancer, or how DNA repair proteins may be targeted for advanced cancer therapies.